Human Cancer Genomes Display Recurrent Repeat Expansions

Expansion of a single repetitive DNA sequence, termed a tandem repeat (TR), is known to cause more than 50 diseases. In some cancers, mutations accumulate in short tracts of TRs, a phenomenon termed microsatellite instability; however, larger repeat expansions have not been systematically analysed in cancer. New findings Ref suggest that rREs may be an important but unexplored source of genetic variation in human cancer, and provide a comprehensive catalogue for further study.

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