New cancer-killing pill annihilates tumors
Hossein Fallahi
August 26, 2023
Gu et al. check this paper used crystallography-directed medicinal chemistry to identify a small molecule ligand of PCNA that interferes with the resolution of transcription replication conflicts. This compound was found to be orally active and inhibited tumor growth in animals without causing any discernable toxicity even at 6 times its effective dose