Exhaustion-associated cholesterol deficiency dampens the cytotoxic arm of antitumor immunity
Hossein Fallahi
May 27, 2023
In this new paper, the author identified the key regulators of T cell cholesterol deficiency in the TME and revealed the mechanism by which cholesterol deficiency drove T cell exhaustion and dysfunction. A new cholesterol-modulation strategy has been developed to improve the performance of CAR-T cells in treating solid tumor.