Metabolic programming and immune suppression in the tumor microenvironment
Hossein Fallahi
February 23, 2023
Increased glucose metabolism and uptake are characteristic of many tumors and used clinically to diagnose and monitor cancer progression. In addition to cancer cells, the tumor microenvironment (TME) encompasses a wide range of stromal, innate, and adaptive immune cells. Cooperation and competition between these cell populations supports tumor proliferation, progression, metastasis, and immune evasion. In this new Review Paper, the authors discussed how metabolic programming of cells within the TME promotes tumor proliferation, progression, and metastasis.