High-performance multiplex drug-gated CAR circuits

Chimeric antigen receptor (CAR) T cells can revolutionize cancer medicine. However, overactivation, lack of tumor-specific surface markers, and antigen escape have hampered CAR T cell development. A multi-antigen targeting CAR system regulated by clinically approved pharmaceutical agents is needed. Li et al paper has developed a multiplex CAR circuits with advanced functionalities.

Previous post
Breast Cancer Epiderivers Next post
Mutations in epigenetic regulators bring fitness to Cancer