Tumor-intrinsic SIRPA promotes sensitivity to checkpoint inhibition immunotherapy in melanoma
Hossein Fallahi
November 08, 2022
Immunotherapy presented new hopes for melanoma patients; however, resistance to this therapy is an issue for many patients. Zhou et al. see the paperpropose a mechanism for signal-regulatory protein α1 (SIRPα) expression and describe how its loss may contribute to immunotherapy resistance.